Thanks in a large part goes to the United States Food and Drugs Administration, for making global assessment a contributing part of the assessment of all patients with Alzheimer’s Disease in clinical trials and Thanks in a large part goes to the United States Food and Drugs Administration, for making global assessment a contributing part of the assessment of all patients with Alzheimer’s Disease in clinical trials and is finding its way into clinical practice. The underlying thought is that an assessment by a clinician, often supplemented by an informant history, provides information on severity that neither a cognitive assessment nor a functional assessment by its self can provide. One such scale, “the Clinicians Interview of Change’, has become widely used in this context and is a rather interesting attempt to semi formalize the routine clinical impression without relying on a whole mess of operationalized criteria.
Specific treatments for AD have been developed, concentrating in clinical trials on making better the core symptom of cognitive impairment. The cholinomimetic approaches are the most advanced, but other therapies are receiving extensive evaluation also. Although designed for the large part as strategies to greatly enhance cognition, these compounds also favourably appear to affect function and may reduce behavioural disturbance. Further evaluation is being conducted to determine whether there are disease-modifying effects or not. A quick look for drugs for cognitive disorders will answer this .
Obese people are at a higher risk of developing Alzheimer’s, and this finding has been replicated in mice: in a couple of clinical trials, Alzheimer’s mice developed 30-50% less plaque when fed on calorie-restricted or low carbohydrate diets. Aged, genetically engineered mice predisposed to Alzheimer’s disease that were fed the fish oil DHA (docosahexaenoic acid), an omega-3 fatty acid, developed significantly less amyloid protein in there brain. The researchers hope that future clinical trials will give similar results. Oxidative processes are associated with Alzheimer’s, and mice predisposed to Alzheimer’s have more oxidative stress or brain damage than normal mice. This explains why vitamin E temporarily slows down disease progression in some Alzheimer’s patients.
New Research tool
Neuroracer is purely a research tool and is not a product available for commercial consumption. Akili Interactive Labs is developing a clinical product in the form of a mobile video game (“Project: EVO”) that is based on the technology behind Neuroracer. The company is currently running clinical trials which will further validate the utility of the new game for use in specific populations. Until those trials are complete, the game will not be available to the general public. We encourage you to visit the Akili website for further news or additional relevant information.
The researchers brought together data from 11 randomised clinical trials involving 22,000 people which compared the effect of B vitamins on the cognitive function in older people against a placebo. Participants receiving B vitamins did see a reduction in the levels of homocysteine in their blood by around a quarter. Sadly though, this had no effect on their cognitive mental abilities.
Alzheimer’s disease research has come a long ways, It’s developed to a point where scientists can look beyond treating symptoms alone, to think about addressing underlying disease processes. In ongoing clinical trials, scientists are developing and testing several possible interventions, including immunization therapy, drug therapies, cognitive training, physical activity, and treatments used for cardiovascular disease and diabetes.
One of the most widely published reports is from DR. Newport. Her husband had been diagnosed with early onset alzheimer’s and was having to watch her husband quickly deteriorate. After using drugs that slow down the effects of Alzheimer’s. She then looked into clinical trials and found one based on MCTs that not only slowed the progression of Alzheimer’s but also offered improvements. She tried to get him involved in the clinical trial but was not successful so she began to give her husband Virgin Coconut Oil, and saw incredible improvement in his condition.
If you are interested in joining a clinical trial I would FIrst check out the ” Fox TRial Finder’, a Web-based solution designed to introduce willing volunteers with the clinical trials that so urgently need them. Using state-of-the-art technology, Fox Trial Finder compares volunteer information, like location and medical history, with clinical trial eligibility requirements to find the best potential matches at study sites close to where you live.
I Have Alzheimer’s