MAGNETIC RESONANCE IMAGINING (MRI)of the cerebral cortex thickness of elderly subjects showed that characteristic structural changes can be identified two years before diagnostic behavioral symptoms become manifest in the brain. MRI abnormalities appear with behavioral symptoms and the neurodegeneration indicated with (MRI) occurs in parallel with cognitive decline. An MRI study of about 500 subjects for six months showed that in AD subjects ventricular enlargement was 60% greater than subjects with mild cognitive impairment and 4 times greater than normal elderly controls – and ventricular enlargements was greater AD victims having one APOE-4 allele than those having none.
This same group in their most recent the team requited 54 subjects, which they treated at the memory and aging center, at the university of California between the years of 2007 and 2012. Every subject had either mild AD(42 people) or a condition known as amnestic mild cognitive impairment, described as a very early stage of AD (12 people). The participants who had amnestic mild cognitive impairment along with 35 of the 42 those with AD also had epilepsy; and the remaining 7 with AD had previously had epileptic activity recorded in their brains but they didn’t experience seizures- this will be referred to as subclinical epilepsy. Having identified all the study participants. the scientists examined all of the patients medical records and put together a range of information that included their ethnicity; there economic status; their seizure typesthe nature and timing of their cognitive decline, and their response to anti-epileptic drugs. they also took a look at at the medical records of a similar groupof people who had Ad but didn’t have the history of seizures or epilectic activities as the first group had, to find out if having siezures had an impact on the rate of cognitive decline.
In their most recent study the team recruited 54 people who were treated at the Memory and Ageing Centre, at the University of California, between 2007 and 2012. All had either mild AD (42 people) or a condition known as amnestic mild cognitive impairment (described as a very early stage of AD – 12 people). The participants who had amnestic mild cognitive impairment, and 35 of the 42 those with AD, also had epilepsy; and the remaining seven people with AD had previously had epileptic activity recorded in their brains but they did not experience seizures (this will be referred to as subclinical epilepsy). Having identified the study participants, the scientists examined all of their medical records, and collected a range ofinformation including: their ethnicity; their economic status; their seizure type(s); the nature/timing of their cognitive decline, and their response to anti-epileptic drugs (AEDs). They also looked at the medical records of a similar group of people who had AD but no history of seizures/epileptic activity, to find out if having seizures had an impact on the rate of cognitive decline
Partly because of the difficulty in detecting early stage ALzheimer’s or mild cognitive impairment (MCI), many with the disease remain undiagnosed, Hopefully with research and time out ability to detect detect early stage alzheimer’s will continue to improve, it will increase the number of people diagnosed with Alzheimer’s Disease.
Mild Cognitive impairment actually a relative recent term used to describe people who have some proplems with memory but who don’t actually have dementia, since dementia is actually defined as having problems in two or more cognitive domains. Some of these patiensts will be in an early stages of alzheimer’s or another stage of dementia, so it’s crucial to identify them. Finding MTA is a strong risk factor for progression to dementia.
Alzheimer’s disease is the most common form of Dementia among older person. Dementia is a brain disorder that seriously affects a persons ability to carry out daily activities. it first involves the part of the brain that controls thought, memory and language. People with AD may have trouble remembering things that happened a few days ago or the names of people they know. A related problem, mild cognitive impairment (MCI)causes more memory problems than normal for people of the same age.
it is almost impossible to write an article of this nature without getting too technical in nature . I would need to offer reference information since because of the technical nature of the subjects. Let it suffice to say that I believe that Mild Cognitive impairment is definitely part of the beginning stages of Alzheimer’s Disease. I yield to those who know a lot more than me.
I Have Alzheimer’s